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Torday-Rehan Lab HARBOR-UCLA

  
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Symposium held at the 2nd International Congress for Respiratory Science, Bad Honnef, Germany, Aug 12, 2009, entitled:

Leptin Integrates Vertebrate Evolution: from Oxygen to the Blood-Gas Barrier


Chair: John S. Torday,PhD, Professor of Pediatrics, UCLA

Goals of the symposium:
To delineate the blood-gas barrier phenotype across vertebrate species
(Powell); to demonstrate the interrelationship between the evolution of
the Blood-Gas Barrier, locomotion and metabolism (Farmer); to introduce
the selection pressures for the evolution of the surfactant system as a
part of the Blood-gas Barrier (Orgeig); to introduce the lung
lipofibroblast and its product, leptin, which coordinately regulates
surfactant,type IV collagen in the basement membrane and host defense,
as the cell-molecular site of selection pressure for the Blood-Gas
Barrier (Torday); to drill down to the Gene Regulatory Network(s)
involved in leptin signaling and the Blood-Gas Barrier phenotype
(Nielsen); to extend the relationship between leptin and the
blood-gas-barrier to diving mammals (Ailsa Hall).

Speakers/Titles
Frank Powell- The structure and function of the Blood-Gas Barrier
Colleen Farmer- Was the blood gas barrier a constraint on activity
metabolism and thereby body size of Mesozoic mammals?
Sandra Orgeig- The evolutionary selection pressures for the pulmonary
surfactant system as part of the Blood-Gas Barrier
John Torday- Leptin signaling and the Evolution of the Blood-Gas Barrier
Heber Nielsen- Leptin signaling and the Epidermal Growth Factor Pathway
in the formation and homeostatic regulation of the Blood-Gas Barrier
Ailsa Hall- Evolution of the Blood-Gas Barrier in Diving Mammals

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SICB 2009 Boston,MA

Cell-Cell Signaling Drives the Evolution of Complex Traits

The global concept of this symposium is that cell-cell signaling has ‘driven’ the vertical integration of vertebrate evolution. Among the principle vertebrate organs and systems there is a direct relationship between cell signaling and structure-function relationships in development, homeostasis, repair and aging. These mechanisms become progressively more derivative over evolutionary time, as the selection pressure becomes one for the interrelationships between organs- respiration and metabolism, metabolism and photoreception, respiration as Radical Oxygen Species and signal transduction. The speakers will address these hierarchical interrelationships in their models and mechanisms of choice.

 

Tadpole (Torday)

Wolf (Crockford)

Sponges (Leys and Nichols)

Ciona intestianlis (Brad Davidson)

Darwin’s Finch (Abzhanov)

Zebrafish (Cannon)

Alligator (Owerkowicz)

 
 
  1. John Torday, Professor of Pediatrics, UCLA- “Introduction: Cell-cell signaling and lung evo-devo”.
  2. Susan Crockford, Assistant Professor, University of Victoria. “Evolution of Endocrine Mechanisms”
  3. Sally Leys, Assistant Professor, University of Alberta- “The Evolution of Vertebrate Body Plans”
  4. Scott Nichols, Post-Doctoral Student, UC-Berkley- “Cell-Cell Signaling and the Origins of Vertebrate Evolution”
  5. Brad Davidson, Assistant Professor, Dept. of Molecular and Cellular Biology, University of Arizona, “Evolution of the Heart”
  6. Marty Cohn, U.Florida at Gainesville. Evolution of the urogenital tract?
  7. Nadia Mezentseva, Graduate Student, New York Medical College, Department of Cell Biology and Anatomy, “Evolution of Thermogenesis”.
  8. Arkhat Abzhanov, Associate Professor, Harvard Medical School: “How Darwin’s Finches Got Their Beaks”
  9. John P. Cannon, Assistant Professor of Immunology, U.Florida, “Evolution of Immunity”.
  10. Tomasz Owerkowicz, Post-Doctoral Fellow, UC-Irvine, Dept of Ecology and Evolutionary Biology, “Evolution of the Cardiopulmonary System”.
  11. Jim Hicks, Comparative Physiology, UCI “How to Integrate Cell-Mol Evolution”
  

“Evolution and Medicine: How New Applications Advance Research and Practice”
Henry Stewart lecture “Lung Biology and Lung Disease, J.S.Torday,MSc,PhD, Professor of Pediatrics/Ob-Gyn, David Geffen School of Medicine, UCLA,Los Angeles,CA”
       
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